Tomohiro Nishino

Oct 23, 2024 | nature.com | Michael Alexanian |Tomohiro Nishino |Lin Ye |Clara Lee |Will Flanigan |Zachary Gardner | +7 more

AbstractChronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel maladaptive cell state transitions1 and pathological interaction between cellular compartments.

Feb 22, 2024 | nature.com | Arun Padmanabhan |Angelo Pelonero |Tomohiro Nishino |Lin Ye |Andrey Poleshko |Michael Alexanian | +2 more

AbstractHuman induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a hiPSC to CM differentiation system and reveal here that BRD4, a member of the bromodomain and extraterminal (BET) family, regulates CM differentiation.