Anh Tuan Vuong

1 week ago | biorxiv.org | Aniket Joshi |Anh Tuan Vuong |Bowen Xu |Ravi Singh

AbstractCancer-driven cachexia is a deleterious syndrome which involves progressive loss of skeletal muscle mass with or without fat loss, fatigue, and weakness that cannot be reversed by nutritional intake. Recent studies have shown deregulation of endoplasmic reticulum (ER)-induced unfolded protein response (UPR) pathways in skeletal muscles in various catabolic conditions, including cancer growth.

Oct 6, 2024 | biorxiv.org | Anirban Roy |Aniket Joshi |Anh Tuan Vuong |Cristeena Josphien

AbstractCachexia is an involuntary loss of body weight mostly due to skeletal muscle wasting. The proinflammatory cytokine TWEAK and its receptor Fn14 constitute a major signaling system that regulates skeletal muscle mass in diverse conditions. However, the role of TWEAK/Fn14 system in the regulation of skeletal muscle mass during cancer-induced cachexia remains poorly understood.