Aniket Joshi

1 week ago | biorxiv.org | Aniket Joshi |Anh Tuan Vuong |Bowen Xu |Ravi Singh

AbstractCancer-driven cachexia is a deleterious syndrome which involves progressive loss of skeletal muscle mass with or without fat loss, fatigue, and weakness that cannot be reversed by nutritional intake. Recent studies have shown deregulation of endoplasmic reticulum (ER)-induced unfolded protein response (UPR) pathways in skeletal muscles in various catabolic conditions, including cancer growth.

Jan 28, 2025 | insight.jci.org | JCI Insight |Aniket Joshi |Ashok Kumar

ResearchCell biologyMuscle biologyStem cellsOpen Access | 10.1172/jci.insight.187825 JCI Insight. https://doi.org/10.1172/jci.insight.187825. Copyright © 2025, Tomaz da Silva et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractSkeletal muscle regeneration in adults is predominantly driven by satellite cells.

Oct 10, 2024 | digitalcommons.library.tmc.edu | Aniket Joshi |Tatiana E. Koike |Anirban Roy |Kavya Mathukumalli

AbstractSkeletal muscle atrophy is a prevalent complication in multiple chronic diseases and disuse conditions. Fibroblast growth factor-inducible 14 (Fn14) is a member of the TNF receptor superfamily and a bona fide receptor of the TWEAK cytokine. Accumulating evidence suggests that Fn14 levels are increased in catabolic conditions as well as during exercise. However, the role of Fn14 in the regulation of skeletal muscle mass and function remains poorly understood.

Oct 6, 2024 | biorxiv.org | Anirban Roy |Aniket Joshi |Anh Tuan Vuong |Cristeena Josphien

AbstractCachexia is an involuntary loss of body weight mostly due to skeletal muscle wasting. The proinflammatory cytokine TWEAK and its receptor Fn14 constitute a major signaling system that regulates skeletal muscle mass in diverse conditions. However, the role of TWEAK/Fn14 system in the regulation of skeletal muscle mass during cancer-induced cachexia remains poorly understood.

Oct 6, 2024 | biorxiv.org | Aniket Joshi |Ashok Kumar

AbstractSkeletal muscle regeneration in adults is predominantly driven by satellite cells. Loss of satellite cell pool and function leads to skeletal muscle wasting in many conditions and disease states. Here, we demonstrate that the levels of fibroblast growth factor-inducible 14 (Fn14) are increased in satellite cells after injury. Conditional ablation of Fn14 in Pax7-expressing satellite cells drastically reduces their expansion and skeletal muscle regeneration following injury.