Aniruddha Deshpande

Dec 2, 2024 | nature.com | Aniruddha Deshpande |David Scott

AbstractMacropinocytosis has emerged as a scavenging pathway that cancer cells exploit to survive in a nutrient-deprived microenvironment. Tumor cells are especially reliant on glutamine for their survival, and in pancreatic ductal adenocarcinoma (PDAC) cells, glutamine deficiency can enhance the stimulation of macropinocytosis. Here, we identify the atypical protein kinase C (aPKC) enzymes, PKCζ and PKCι, as regulators of macropinocytosis.

Feb 5, 2024 | audiologyonline.com | Aniruddha Deshpande

Please note that to complete this course, you will need to read the textbook Tinnitus: Advances in Prevention, Assessment, and Management. If you do not already have a copy of the textbook, you can purchase it at Plural Publishing, Inc. What is a textbook CE course? Our textbook CE courses constitute the CE activity for their respective textbooks. Essentially, these courses provide a way to earn CEUs for the time and effort our members invest in reading these valuable texts.

Nov 9, 2023 | nature.com | Meghana S. Pagadala |Jon Larson |L. T. Hung |Nicole G. Coufal |Howard Chang |Jesse R. Dixon | +8 more

AbstractCircular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and reconstruction of ecDNA across a retrospective cohort of 481 medulloblastoma tumors from 465 patients, we identify circular ecDNA in 82 patients (18%).