Annalisa L.E. Carli

Sep 17, 2024 | science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook |Annalisa L.E. Carli

Editor’s summaryThe serine/threonine kinase DCLK1 is a putative cancer stem cell marker that is associated with the progression of gastric cancers. Afshar-Sterle et al. found that mutating the kinase domain of DCLK1 or inhibiting its kinase activity reduced tumor growth, abundance of markers of stromal remodeling, and induction of epithelial-to-mesenchymal transition (EMT).