Shoukat Afshar-Sterle

Sep 17, 2024 | science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook

Editors' ChoiceMETABOLISMAnnalisa M. VanHook https://orcid.org/0000-0002-5989-6767Authors Info & AffiliationsAbstractThe taurine metabolite N-acetyltaurine protects mice from diet-induced obesity by reducing food intake.

Sep 17, 2024 | science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook |Annalisa L.E. Carli

Editor’s summaryThe serine/threonine kinase DCLK1 is a putative cancer stem cell marker that is associated with the progression of gastric cancers. Afshar-Sterle et al. found that mutating the kinase domain of DCLK1 or inhibiting its kinase activity reduced tumor growth, abundance of markers of stromal remodeling, and induction of epithelial-to-mesenchymal transition (EMT).

Sep 17, 2024 | science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook |Mizuho Horioka-Duplix

AbstractIn contrast with sun exposure–induced melanoma, rarer melanocytic tumors and neoplasms with low mutational burden present opportunities to study isolated signaling mechanisms. These include uveal melanoma and blue nevi, which are often driven by mutations within the G protein–coupled signaling cascade downstream of cysteinyl leukotriene receptor 2.