AnnaLynn M. Williams

Nov 20, 2023 | jamanetwork.com | AnnaLynn M. Williams |Jeanne S. Mandelblatt |Mingjuan Wang |Qian Dong

Key PointsQuestion  Is the deficit accumulation index (DAI), a clinical measure of physiological aging, associated with biomarkers of aging, such as epigenetic age acceleration (EAA) and mean leukocyte telomere length, in survivors of childhood cancer? Findings  In this cross-sectional study of 2101 survivors of childhood cancer, the DAI was associated with EAA but not mean leukocyte telomere length. Both the DAI and EAA were highly effective at identifying aging phenotypes.

May 31, 2023 | jamanetwork.com | Nicholas Phillips |Kayla Stratton |AnnaLynn M. Williams |Tim A. Ahles

Key PointsQuestion  Are adult survivors of childhood cancer at risk for new-onset neurocognitive impairments that outpace those associated with typical aging? Findings  In this cohort study of 2375 adult survivors of childhood cancer and their sibling controls, new-onset memory impairment emerged more often in survivors decades after cancer diagnosis and treatment. The increased risk was associated with cancer treatment, modifiable health behaviors, and chronic health conditions.