Jeanne S. Mandelblatt

Dec 8, 2024 | jamanetwork.com | Eric J. Feuer |Jeanne S. Mandelblatt |Rafael Meza |Theodore R. Holford

Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020 Podcast (16:08) 0:00 / 0:00 Key PointsQuestion  What is the contribution of prevention, screening (to remove precursors [interception] or early detection), and treatment interventions to deaths averted in breast, cervical, colorectal, lung, and prostate cancer from 1975 to 2020?

Apr 29, 2024 | jamanetwork.com | Jeanne S. Mandelblatt |Candace Mainor |Barry I. Hudson

The Alliance trial led by Chen and colleagues1 and published in this issue of JAMA addresses an important topic in the management of breast cancer: can daily use of 300 mg of aspirin improve invasive disease–free survival among persons with a diagnosis of nonmetastatic, high-risk breast cancer? The answer is a fairly definitive no based on prespecified futility rules in a rigorous phase 3, randomized, placebo-controlled, double-blind trial.

Mar 29, 2024 | nature.com | Jeanne S. Mandelblatt

A study reports that survivors of childhood cancer age faster than healthy controls and have increased risk of frailty and death; however, heterogeneity in outcomes was present, indicating inequities in risk. Knowledge about aging in high-risk groups holds the potential to identify interventions to improve survivorship outcomes.

Nov 22, 2023 | jamanetwork.com | Amy B. Knudsen |Amy Trentham-Dietz |Jane Kim |Jeanne S. Mandelblatt

Key PointsQuestion  How many lung, colorectal, breast, and cervical cancer deaths could be prevented with a 10–percentage point increase in screening utilization for each cancer?

Nov 20, 2023 | jamanetwork.com | AnnaLynn M. Williams |Jeanne S. Mandelblatt |Mingjuan Wang |Qian Dong

Key PointsQuestion  Is the deficit accumulation index (DAI), a clinical measure of physiological aging, associated with biomarkers of aging, such as epigenetic age acceleration (EAA) and mean leukocyte telomere length, in survivors of childhood cancer? Findings  In this cross-sectional study of 2101 survivors of childhood cancer, the DAI was associated with EAA but not mean leukocyte telomere length. Both the DAI and EAA were highly effective at identifying aging phenotypes.