Mingjuan Wang

Nov 20, 2023 | jamanetwork.com | AnnaLynn M. Williams |Jeanne S. Mandelblatt |Mingjuan Wang |Qian Dong

Key PointsQuestion  Is the deficit accumulation index (DAI), a clinical measure of physiological aging, associated with biomarkers of aging, such as epigenetic age acceleration (EAA) and mean leukocyte telomere length, in survivors of childhood cancer? Findings  In this cross-sectional study of 2101 survivors of childhood cancer, the DAI was associated with EAA but not mean leukocyte telomere length. Both the DAI and EAA were highly effective at identifying aging phenotypes.