Anthony J. Saviola

1 month ago | biorxiv.org | Mark Wilkinson |Cassandra M Modahl |Anthony J. Saviola |Laura-Oana Albulesco

AbstractThe puff adder (Bitis arietans) is a highly venomous viper responsible for many fatalities in Africa, yet there have been few comprehensive analyses of its venom proteins, particularly of the proteases that play a key role in pathology of envenoming. To address this, we have isolated, identified and characterised the bioactivity of the venom metalloproteases of puff adders obtained from a wide range of sources. Prominent in all venoms was an SVMP PI, derived from a PII precursor.

2 months ago | cell.com | Benjamin Erickson |Roman O Fedoryshchak |Nova Fong |Ryan Sheridan |Keira larson |Anthony J. Saviola | +4 more

KeywordsPol II CTD Ser5 phosphorylationCTD dephosphorylationPP1 phosphataserestrictorWDR82ZC3H4transcription terminationtranscription elongationResearch topic(s)CP: Molecular biologyIntroductionA large fraction of promoters in multicellular organisms have bidirectional character and give rise to both sense and divergent antisense transcription, which must eventually terminate to prevent interference with neighboring genes and collisions with replication forks.

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.