Antonia Terrizzano

2 months ago | digitalcommons.library.tmc.edu | Hongsu Wang |Kelvin Yeung |Carolyn Morrison |Antonia Terrizzano

Nature Communications 10.1038/s41467-024-51429-z Post-print yes Animals, Drosophila Proteins, Transcription Factors, ErbB Receptors, Drosophila melanogaster, Signal Transduction, Gene Expression Regulation, Developmental, Neurons, DNA-Binding Proteins, Cell Differentiation, Photoreceptor Cells, Invertebrate, Eye Proteins, Imaginal Discs, Nerve Tissue Proteins, Proto-Oncogene Proteins, Receptors, Invertebrate Peptide, Differentiation, Transcriptomics, Developmental neurogenesis,...

Aug 17, 2024 | nature.com | Hongsu Wang |Kelvin Yeung |Carolyn Morrison |Cornelia Fritsch |Simon G. Sprecher |Graeme Mardon | +1 more

AbstractThe integration of extrinsic signaling with cell-intrinsic transcription factors can direct progenitor cells to differentiate into distinct cell fates. In the developing Drosophila eye, differentiation of photoreceptors R1–R7 requires EGFR signaling mediated by the transcription factor Pointed, and our single-cell RNA-Seq analysis shows that the same photoreceptors require the eye-specific transcription factor Glass.