Arthur D Lander

Jul 24, 2024 | nature.com | Peng Dong |Shu Zhang |Andrew L. Lemire |Arthur D Lander |Howard Chang

AbstractThe contrast between the disruption of genome topology after cohesin loss and the lack of downstream gene expression changes instigates intense debates regarding the structure–function relationship between genome and gene regulation.

Jan 25, 2024 | biorxiv.org | Michael Caldwell |Arthur D Lander |UC Irvine

AbstractTissues achieve and maintain their sizes through active feedback, whereby cells collectively regulate proliferation and differentiation so as to facilitate homeostasis and the ability to respond to disturbances. One of the best understood feedback mechanisms--renewal control--achieves remarkable feats of robustness in determining and maintaining desired sizes.