Axe Neurosciences

Nov 20, 2024 | academic.oup.com | Université Laval |Axe Neurosciences |Faculté de Médecine

PDF Split View Geoffrey Canet, Emmanuel Planel, Proteostasis restoration: a new metric for tau immunotherapy efficacy, Brain, Volume 148, Issue 1, January 2025, Pages 9–11, https://doi.org/10.1093/brain/awae382 Close This scientific commentary refers to ‘Proteostasis as a fundamental principle of Tau immunotherapy’ by Cruz et al. (https://doi.org/10.1093/brain/awae254).

Jan 28, 2024 | link.springer.com | Axe Neurosciences |Quebec City |Université Laval

AbstractThis study aimed to investigate the clinical stratification of amyotrophic lateral sclerosis (ALS) patients in relation to in vivo cerebral degeneration. One hundred forty-nine ALS patients and one hundred forty-four healthy controls (HCs) were recruited from the Canadian ALS Neuroimaging Consortium (CALSNIC). Texture analysis was performed on T1-weighted scans to extract the texture feature “autocorrelation” (autoc), an imaging biomarker of cerebral degeneration.

Nov 1, 2023 | journals.aai.org | Axe Neurosciences

Th1 cells are critical in experimental autoimmune encephalomyelitis (EAE). Serine protease inhibitor clade E1 (Serpine1) has been posited as an inhibitor of IFN-γ from T cells, although its role in autoimmunity remains unclear. In this study, we show that Serpine1 knockout (KO) mice develop EAE of enhanced severity relative to wild-type (WT) controls.

Jul 17, 2023 | frontiersin.org | Cape Town |Axe Neurosciences |Université Laval

A review of the auditory-gut-brain axis Amy S. Graham1, 2*, Benneth Ben-Azu3, 4, Marie-Ève Tremblay4, 5, 6, 7, 8, 9, 10, Peter Torre III11, Marjanne Senekal12, Barbara Laughton13, Andre van der Kouwe14, 15, Marcin Jankiewicz1, 2, Mamadou Kaba16 and Martha J.