Axel Nordenskjöld

Oct 2, 2024 | nature.com | Robert Sigström |Andreas Göteson |Axel Nordenskjöld |Kaj Blennow |Henrik Zetterberg

AbstractDespite electroconvulsive therapy (ECT) being recognized as an effective treatment for major depressive episodes (MDE), its application is subject to controversy due to concerns over cognitive side effects. The pathophysiology of these side effects is not well understood. Here, we examined the effects of ECT on blood-based biomarkers of neuronal injury and astrocytic reactivity. Participants with a major depressive episode (N = 99) underwent acute ECT.