Andreas Göteson

Oct 2, 2024 | nature.com | Robert Sigström |Andreas Göteson |Axel Nordenskjöld |Kaj Blennow |Henrik Zetterberg

AbstractDespite electroconvulsive therapy (ECT) being recognized as an effective treatment for major depressive episodes (MDE), its application is subject to controversy due to concerns over cognitive side effects. The pathophysiology of these side effects is not well understood. Here, we examined the effects of ECT on blood-based biomarkers of neuronal injury and astrocytic reactivity. Participants with a major depressive episode (N = 99) underwent acute ECT.

Aug 28, 2024 | nature.com | Jiantao Chen |Zhijian Yang |Ranran Zhai |Xiao Feng |Ting Li |Denis Maslov | +25 more

AbstractUnderstanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.