Axel Poulet

Sep 19, 2024 | cell.com | Kidney Diseases |Miguel Almeida |Axel Poulet |Bioinformatics Group

Keywords PIWI piRNA spermatogenesis readthrough transcription stress evolution fertility transposon mobile genetic element germ cell Research topic(s) CP: Molecular biology Introduction PIWI-interacting RNAs (piRNAs) and their PIWI protein partners are essential for germ cell health and the survival of species.1,2,3,4,5 piRNA pathways establish restriction of mobile genetic elements to protect genome integrity.6,7 Mutations in essential piRNA pathway genes result in sterility in animals and...

Oct 6, 2023 | science.org | Guan-Hua Su |Susan Athey |Koon-Kiu Yan |Axel Poulet

Research ArticleDEVELOPMENTAL BIOLOGYINTRODUCTIONPluripotent stem cells are present in all metazoans. In many animals, and in particular in the most common animal model systems, such stem cells are restricted to the early stages of embryonic development. Most of our understanding of pluripotency thus relies on studies of embryonic (or induced) pluripotent cells from vertebrate models that naturally maintain these cells only for a brief period of time and in a closely protected environment.