Bahne H. Bahners

Mar 7, 2024 | nature.com | Rachel K. Spooner |Bahne H. Bahners |Alfons Schnitzler

AbstractSubthalamic deep brain stimulation (STN-DBS) is an effective therapy for alleviating motor symptoms in people with Parkinson’s disease (PwP), although some may not receive optimal clinical benefits. One potential mechanism of STN-DBS involves antidromic activation of the hyperdirect pathway (HDP), thus suppressing cortical beta synchrony to improve motor function, albeit the precise mechanisms underlying optimal DBS parameters are not well understood.

Oct 30, 2023 | biorxiv.org | Bahne H. Bahners |Roxanne Lofredi |Alfons Schnitzler |Tillmann Sander

AbstractBackground: Deep brain stimulation (DBS) has strong beneficial effects for treating movement disorders. The related cortical mechanisms can be studied with magnetoencephalography (MEG) during active DBS. However, MEG is prone to artefacts induced by the electrical stimulation and the movement of ferromagnetic DBS components. Although artefacts might vary between DBS devices from different manufacturers, no such comparison has been performed.

Mar 11, 2023 | nature.com | Alfons Schnitzler |Rachel K. Spooner |Bahne H. Bahners

AbstractAlthough subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson’s disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes for optimizing DBS parameter settings, which may contribute to treatment inefficacies.