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Jul 19, 2024 | 
biorxiv.org | Christian Hartmann |Markus Butz |Alfons Schnitzler |Marius Kroesche
AbstractBesides parkinsonism, higher order cortical dysfunctions such as apraxia are hallmarks of the corticobasal syndrome (CBS). To date, little is known about the electrophysiological underpinnings of these symptoms. To shed more light on the pathophysiology of CBS, we recorded the magnetoencephalogram of 17 CBS patients and 20 age-matched controls engaged in an observe-to-imitate task.
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Jul 19, 2024 | biorxiv.org | Christian Hartmann |Markus Butz |Alfons Schnitzler |Marius Kroesche
AbstractBesides parkinsonism, higher order cortical dysfunctions such as apraxia are hallmarks of the corticobasal syndrome (CBS). To date, little is known about the electrophysiological underpinnings of these symptoms. To shed more light on the pathophysiology of CBS, we recorded the magnetoencephalogram of 17 CBS patients and 20 age-matched controls engaged in an observe-to-imitate task.
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Jul 12, 2024 | 
journals.plos.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Heinrich Heine Düsseldorf
Citation: Erfanian Abdoust M, Froböse MI, Schnitzler A, Schreivogel E, Jocham G (2024) Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS Biol 22(7): e3002714. https://doi.org/10.1371/journal.pbio.3002714Academic Editor: Raphael Samuel Matthew Kaplan, Universitat Jaume 1, SPAINReceived: December 14, 2023; Accepted: June 14, 2024; Published: July 12, 2024Copyright: © 2024 Erfanian Abdoust et al.
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Apr 20, 2024 | 
biorxiv.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Elisabeth Schreivogel
AbstractIn everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes.
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Mar 7, 2024 | 
nature.com | Rachel K. Spooner |Bahne H. Bahners |Alfons Schnitzler
AbstractSubthalamic deep brain stimulation (STN-DBS) is an effective therapy for alleviating motor symptoms in people with Parkinson’s disease (PwP), although some may not receive optimal clinical benefits. One potential mechanism of STN-DBS involves antidromic activation of the hyperdirect pathway (HDP), thus suppressing cortical beta synchrony to improve motor function, albeit the precise mechanisms underlying optimal DBS parameters are not well understood.
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Jan 29, 2024 | 
biorxiv.org | Michelle Johannknecht |Alfons Schnitzler |Joachim Lange
AbstractWhen presented shortly after another, discrete pictures are naturally perceived as continuous. The neuronal mechanism underlying such continuous or discrete perception are not well understood. While continuous alpha oscillations are a candidate for orchestrating such neuronal mechanisms, recent evidence is mixed. In this study, we investigated the influence of prestimulus alpha oscillation on visual temporal perception.
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Nov 21, 2023 | 
biorxiv.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Elisabeth Schreivogel
AbstractIn everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes.
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Oct 30, 2023 | 
biorxiv.org | Bahne H. Bahners |Roxanne Lofredi |Alfons Schnitzler |Tillmann Sander
AbstractBackground: Deep brain stimulation (DBS) has strong beneficial effects for treating movement disorders. The related cortical mechanisms can be studied with magnetoencephalography (MEG) during active DBS. However, MEG is prone to artefacts induced by the electrical stimulation and the movement of ferromagnetic DBS components. Although artefacts might vary between DBS devices from different manufacturers, no such comparison has been performed.
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Mar 11, 2023 | 
nature.com | Alfons Schnitzler |Rachel K. Spooner |Bahne H. Bahners
AbstractAlthough subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson’s disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes for optimizing DBS parameter settings, which may contribute to treatment inefficacies.
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Mar 11, 2023 | 
onlinelibrary.wiley.com | Alfons Schnitzler |Joachim Lange |Frederick Benjamin Junker |Tobias Schmidt-Wilcke
ACC anterior cingulate cortex AG angular gyrus fMRI functional magnetic resonance imaging HPI head position indication IFC inferior frontal cortex IQR interquartile range MC Morse code MEG magnetoencephalography MNI Montreal Neurological Institute PC precuneus ROI region of interest.
