Rachel K. Spooner

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Articles

Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered - npj Parkinson's Disease

Mar 7, 2024 | nature.com | Rachel K. Spooner |Bahne H. Bahners |Alfons Schnitzler

AbstractSubthalamic deep brain stimulation (STN-DBS) is an effective therapy for alleviating motor symptoms in people with Parkinson’s disease (PwP), although some may not receive optimal clinical benefits. One potential mechanism of STN-DBS involves antidromic activation of the hyperdirect pathway (HDP), thus suppressing cortical beta synchrony to improve motor function, albeit the precise mechanisms underlying optimal DBS parameters are not well understood.
Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction - Scientific Reports

Mar 3, 2024 | nature.com | Rachel K. Spooner

AbstractBradykinesia is a behavioral manifestation that contributes to functional dependencies in later life. However, the current state of bradykinesia indexing primarily relies on subjective, time-averaged categorizations of motor deficits, which often yield poor reliability.

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