Rachel K. Spooner

Mar 7, 2024 | nature.com | Rachel K. Spooner |Bahne H. Bahners |Alfons Schnitzler

AbstractSubthalamic deep brain stimulation (STN-DBS) is an effective therapy for alleviating motor symptoms in people with Parkinson’s disease (PwP), although some may not receive optimal clinical benefits. One potential mechanism of STN-DBS involves antidromic activation of the hyperdirect pathway (HDP), thus suppressing cortical beta synchrony to improve motor function, albeit the precise mechanisms underlying optimal DBS parameters are not well understood.

Mar 3, 2024 | nature.com | Rachel K. Spooner

AbstractBradykinesia is a behavioral manifestation that contributes to functional dependencies in later life. However, the current state of bradykinesia indexing primarily relies on subjective, time-averaged categorizations of motor deficits, which often yield poor reliability.

Mar 11, 2023 | nature.com | Alfons Schnitzler |Rachel K. Spooner |Bahne H. Bahners

AbstractAlthough subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson’s disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes for optimizing DBS parameter settings, which may contribute to treatment inefficacies.