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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |J. G. Muir
Editor’s summaryPsychedelics have been recently shown to have therapeutic potential for treating psychiatric conditions. Muir et al. performed single-nucleus RNA sequencing in psychedelic-activated neurons in mouse medial prefrontal cortex. The psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5HT2A receptor agonist with anxiolytic-like effects in mice, activated a specific subset of neurons in this brain region.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Shiqi Fang
Editor’s summaryThe centrality of lithium batteries to renewable energy infrastructure has motivated vigorous research into more efficient lithium sourcing. The oceans contain substantial aggregate quantities of lithium salts, but the comparatively low concentration makes them hard to separate from sodium and magnesium (see the Perspective by Darling). Li et al. now demonstrate a method inspired by the batteries themselves.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Zhen Li
Editor’s summaryThe centrality of lithium batteries to renewable energy infrastructure has motivated vigorous research into more efficient lithium sourcing. The oceans contain substantial aggregate quantities of lithium salts, but the comparatively low concentration makes them hard to separate from sodium and magnesium (see the Perspective by Darling). Li et al. now demonstrate a method inspired by the batteries themselves.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Yi Lu
AbstractPrecise regulation of intracellular phosphate (Pi) is critical for cellular function, with XPR1 serving as the sole Pi exporter in humans. The mechanism of Pi efflux, activated by inositol pyrophosphates (PP-IPs), has remained unclear.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Valda Vinson
Does the information that people see on social media influence their political views? Is it making people politically more divided? In July 2023, Science published three papers on an unprecedented study of the effects of social media and social media algorithms on political polarization during the United States 2020 presidential election.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Peter Stern
Neuroscience Another limitation of working memoryPeter SternMonkeys experience similar challenges in working memory to humans, including erroneously swapping one detail for another. PHOTO: PURIPAT PENPUN/GETTY IMAGESThe well-known limitations of working memory are attributed to the drift of memories over time and the forgetting of items. However, a third type of error, the so-called swap error, is not well understood.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Eric J. Topol
The recent capability to measure thousands of plasma proteins from a tiny blood sample has provided a new dimension of expansive data that can advance our understanding of human health. For example, the company SomaLogic has developed the means to measure more than 10,000 proteins and Thermo Fisher’s Olink assays over 5400 proteins from as little as 2 μl.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Maicon Landim-Vieira
PerspectiveMedicineComparative genomic analyses provide mechanistic clues to cardiac muscle regulationMaicon Landim-Vieira and Jose Renato Pinto Authors Info & AffiliationsScience26 Sep 2024Vol 385, Issue 6716pp. 1420-1421AbstractCardiomyopathies, heart muscle disorders that cause the heart to lose its ability to pump blood effectively, can lead to more serious medical conditions, including irregular heartbeats and cardiac arrest.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Elizabeth Pennisi
Tilted by tectonic forces, gypsum beds nearly 6 million years old in western Greece record the drying of the Mediterranean Sea. PHOTO: KONSTANTINA AGIADIToday tourists flock to the Mediterranean Sea for its beaches and shimmering blue-green waters. It wasn’t so hospitable some 6 million years ago, when the entire sea lost its Atlantic Ocean connection and temporarily dried up, leaving behind a kilometer-thick layer of salt. The basin’s original biodiversity was decimated.
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Sep 26, 2024 | 
science.org | Qiuhe Lu |Z. Chahine |J. G. Muir |Luis A. Campos |Luís Campos
Get full access to this articleView all available purchase options and get full access to this article. References and Notes1N. Wade, Science 187, 931 (1975). 2Attributed to Norton Zinder by Paul Berg; oral history interview, 17 May 1975, Box 1, Folder 8, MC 100, MIT Distinctive Collections. 3P. Berg et al., Science 185, 303 (1974). 4“A caution sign from scientists—to scientists,” New York Times, 21 July 1974, p. 167. 5D. G. Comb to P.
