Barbara Thorand

May 17, 2024 | jcp.bmj.com | Katie Harris |Wolfgang Koenig |Yoav Ben-Shlomo |Barbara Thorand

AbstractAims Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities. Methods Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies.

Sep 7, 2023 | nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01588-w, published online 10 August 2023. In the version of the article originally published, the middle panel in Fig. 3b was mistakenly a duplicate of the upper panel. The figure has now been corrected in the HTML and PDF versions of the article.

Sep 7, 2023 | nature.com | Alessia Faggian |Alessia David |Reedik Mägi |Emma Ahlqvist |Gudmar Thorleifsson |Robert Scott | +37 more

AbstractConventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations.

Aug 10, 2023 | nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more

AbstractCirculating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans).

Feb 24, 2023 | jcp.bmj.com | Katie Harris |Wolfgang Koenig |Yoav Ben-Shlomo |Barbara Thorand

Gordon D O Lowe1, http://orcid.org/0000-0003-2444-2869Katie Harris2, Wolfgang Koenig3,4, Yoav Ben-Shlomo5, Barbara Thorand6,7, Annette Peters6,7, Christa Meisinger8,9, Armin Imhof10, Hugh Tunstall-Pedoe11, Sanne A E Peters2,12,13, Mark Woodward2,13 1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK 2The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia 3German Heart Center Munich, Technical University of...