Bartłomiej Tomasik

Sep 4, 2024 | nature.com | Xiao-feng Zheng |Aniruddha Guha Sarkar |Aleem Syed |Huy Nguyen |Bartłomiej Tomasik |Kaimeng Huang | +3 more

AbstractCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.