Kaimeng Huang

Sep 4, 2024 | nature.com | Xiao-feng Zheng |Aniruddha Guha Sarkar |Aleem Syed |Huy Nguyen |Bartłomiej Tomasik |Kaimeng Huang | +3 more

AbstractCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

Dec 19, 2023 | biorxiv.org | Veronica Rendo |Michael Schubert |Kaimeng Huang |Nicholas Khuu

AbstractChromosomal gains are among the most frequent somatic genetic alterations occurring in cancer. While the effect of sustained oncogene expression has been characterized, the impact of copy-number gains affecting collaterally-amplified "bystander" genes on cellular fitness remains less understood. To investigate this, we built a comprehensive map of dosage compensation across human cancers by integrating expression and copy number profiles from over 8,000 TCGA tumors and CCLE cell lines.