Kaimeng Huang

Sep 4, 2024 | nature.com | Xiao-feng Zheng |Aniruddha Guha Sarkar |Aleem Syed |Huy Nguyen |Bartłomiej Tomasik |Kaimeng Huang | +3 more

AbstractCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

Dec 19, 2023 | biorxiv.org | Veronica Rendo |Michael Schubert |Kaimeng Huang |Nicholas Khuu

AbstractChromosomal gains are among the most frequent somatic genetic alterations occurring in cancer. While the effect of sustained oncogene expression has been characterized, the impact of copy-number gains affecting collaterally-amplified "bystander" genes on cellular fitness remains less understood. To investigate this, we built a comprehensive map of dosage compensation across human cancers by integrating expression and copy number profiles from over 8,000 TCGA tumors and CCLE cell lines.

Mar 27, 2023 | biorxiv.org | Rui Zhou |Michelle Swift |Aleem Syed |Kaimeng Huang

New Results doi: https://doi.org/10.1101/2023.03.27.534416 AbstractExtent and efficacy of DNA end resection at DNA double strand break (DSB)s determines the choice of repair pathway. Here we describe how the 53BP1 associated protein DYNLL1 works in tandem with Shieldin and the CST complex to protect DNA ends. DYNLL1 is recruited to DSBs by 53BP1 where it limits end resection by binding and disrupting the MRE11 dimer.

Mar 13, 2023 | frontiersin.org | Jinbo Cheng |Geoffroy Laumet |Kaimeng Huang

Motoyo Maruyama1,2 Atsushi Sakai1* Tsukasa Fukunaga3,4 Yoshitaka Miyagawa5 Takashi Okada5,6 Michiaki Hamada7,8,9 Hidenori Suzuki1 1Department of Pharmacology, Nippon Medical School, Bunkyo-ku, Japan 2Division of Laboratory Animal Science, Nippon Medical School, Bunkyo-ku, Japan 3Waseda Institute for Advanced Study, Waseda University, Shinjuku-ku, Japan 4Department of Computer Science, Graduate School of Information Science and Technology, The University of Tokyo, Bunkyo-ku, Japan 5Department...