Aleem Syed

Sep 4, 2024 | nature.com | Xiao-feng Zheng |Aniruddha Guha Sarkar |Aleem Syed |Huy Nguyen |Bartłomiej Tomasik |Kaimeng Huang | +3 more

AbstractCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

Sep 11, 2023 | nature.com | Michelle Swift |Rui Zhou |Aleem Syed |Panagiotis A. Konstantinopoulos |Alan D. D’Andrea |Yizhou Joseph He

AbstractThe extent and efficacy of DNA end resection at DNA double-strand breaks (DSB) determine the repair pathway choice. Here we describe how the 53BP1-associated protein DYNLL1 works in tandem with the Shieldin complex to protect DNA ends. DYNLL1 is recruited to DSBs by 53BP1, where it limits end resection by binding and disrupting the MRE11 dimer. The Shieldin complex is recruited to a fraction of 53BP1-positive DSBs hours after DYNLL1, predominantly in G1 cells.

Mar 27, 2023 | biorxiv.org | Rui Zhou |Michelle Swift |Aleem Syed |Kaimeng Huang

New Results doi: https://doi.org/10.1101/2023.03.27.534416 AbstractExtent and efficacy of DNA end resection at DNA double strand break (DSB)s determines the choice of repair pathway. Here we describe how the 53BP1 associated protein DYNLL1 works in tandem with Shieldin and the CST complex to protect DNA ends. DYNLL1 is recruited to DSBs by 53BP1 where it limits end resection by binding and disrupting the MRE11 dimer.