Ben Willem Mol

Jan 5, 2025 | jamanetwork.com | Amsterdam Reproduction |Leon de Wit |Ruben G. Duijnhoven |Ben Willem Mol

Question  In gestational diabetes, is a sequential oral glucose-lowering medication strategy of metformin and additional glyburide, if needed, noninferior to insulin treatment for prevention of large-for-gestational-age infants? Findings  Among 820 participants randomized to oral glucose-lowering medication, 23.9% of infants were large for gestational age compared with 19.9% randomized to insulin, a difference that did not meet the prespecified criteria for noninferiority.

Feb 20, 2023 | obgyn.onlinelibrary.wiley.com | Amsterdam UMC |Amsterdam Reproduction |Eva PAJKRT |Ben Willem Mol

A number of randomised trials have evaluated induction of labour (IoL) versus expectant management (EM) for late preterm prelabour rupture of membranes (PPROM) occurring between 34 and 37 weeks of gestation, including the PPROMEXIL-trials (van der Ham et al. 2012 PLoS Med;9:e1001208; van der Ham et al. Am J Obstet Gynecol 2012;207:276.e1–10) and the PPROMT trial (Morris et al. Lancet 2016;387:444–52).