Leon de Wit

Jan 5, 2025 | jamanetwork.com | Amsterdam Reproduction |Leon de Wit |Ruben G. Duijnhoven |Ben Willem Mol

Question  In gestational diabetes, is a sequential oral glucose-lowering medication strategy of metformin and additional glyburide, if needed, noninferior to insulin treatment for prevention of large-for-gestational-age infants? Findings  Among 820 participants randomized to oral glucose-lowering medication, 23.9% of infants were large for gestational age compared with 19.9% randomized to insulin, a difference that did not meet the prespecified criteria for noninferiority.