Benjamin S. Braun

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Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes - Leukemia

Jul 20, 2024 | nature.com | Johann-Christoph Jann |Benjamin S. Braun |Shai Shimony |Richard Stone |Daniel DeAngelo |Jacqueline Garcia | +1 more

AbstractMutations in the cohesin complex components (STAG2, RAD21, SMC1A, SMC3, and PDS5B) are recurrent genetic drivers in myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML). Whether the different cohesin subunit mutations share clinical characteristics and prognostic significance is not known.

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