Daniel DeAngelo

1 week ago | hardcoredroid.com | Daniel DeAngelo

Odin: Valhalla Rising releases globally for PC and mobile on April 29th. Developed by the South Korean developer Lionheart Studio, MMORPG fans can pre-register now, with preloading available on the 28th. As the name implies, Oden: Valhalla Rising transports players to a seamless open world inspired by Norse mythology. The Norse god Odin has banished Loki to the mortal realm after receiving a vision that the trickster god would soon bring about the apocalypse, Ragnarok.

2 weeks ago | nature.com | Andreas Hochhaus |Dong-Wook Kim |Jorge Cortés |Koji Sasaki |Michael J. Mauro |Timothy Hughes | +7 more

AbstractAsciminib is the first approved BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP). The present final analysis of the phase 1, open-label, nonrandomized trial (NCT02081378) assessed the long-term safety, tolerability, and antileukemic activity of asciminib in 115 patients with chronic myeloid leukemia in chronic phase without the BCR::ABL1T315I mutation who received asciminib 10–200 mg twice daily (BID) or 80–200 mg once daily (cutoff: March 14, 2023).

1 month ago | nature.com | Bijal Shah |Ryan D. Cassaday |Jae Park |Nicolas Boissel |Yi Lin |Gary Schiller | +5 more

AbstractBrexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 CAR T-cell therapy approved in the US to treat adults aged ≥18 years (≥26 years in the EU) with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Brexu-cel showed an overall complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate of 73% (CR rate 60%) and median overall survival (OS) of 25.4 months in 78 patients with R/R B-ALL after 2 years in ZUMA-3.

1 month ago | onclive.com | Daniel DeAngelo

CommentaryVideoMarch 13, 2025Author(s):Fact checked by:,Daniel J. DeAngelo, MD, PhD, discusses the clinical implications of findings from the PATHFINDER trial of avapritinib in advanced ​​systemic mastocytosis. "Regardless of the histologic subtype [of advanced systemic mastocytosis, we saw] very high response rates [with avapritinib that were] very durable [in the PATHFINDER trial].

1 month ago | n4g.com | Daniel DeAngelo

20°10.0DanielDeAngelo|5m ago|Review||Duck Detective: The Secret Salami dives beak-first into the detective genre with an irresistible blend of charm, humor, and noir vibes. Android Duck Detective: The Secret Salami Mobile hardcoredroid.com 60°8.0neil363|271d ago |Review||Review - Duck Detective: The Secret Salami is a wonderfully characterful tale that gets much right, adding up to a memorable if not brief experience.