Shai Shimony

2 months ago | onlinelibrary.wiley.com | Evan Chen |Shai Shimony |Marlise R. Luskin |Richard Stone

Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “NPM1 Alternative Transcripts Are Upregulated in Acute Myeloid and Lymphoblastic Leukemia and Their Expression Level Affects Patient Outcome,” Journal of Translational Medicine 16, no. 1 (2018): 232. 2, , , and , “Acute Myeloid Leukemia Carrying Cytoplasmic/Mutated Nucleophosmin (NPMc+ AML): Biologic and Clinical Features,” Blood 109, no. 3 (2007): 874–885.

Oct 30, 2024 | nature.com | Shai Shimony |Hari Raman |Jonathan Paolino |Richard Stone |Jean M. Connors |Daniel DeAngelo

AbstractAsparaginase (ASP)-containing regimens for acute lymphoblastic leukemia (ALL) are associated with venous thromboembolism (VTE). We evaluated the prevalence, risk factors, role of prophylaxis and clinical impact of VTE among adolescents and young adult (AYA) patients (15–50 years) treated on Dana-Farber Cancer Institute (DFCI) ALL protocols.

Jul 20, 2024 | nature.com | Johann-Christoph Jann |Benjamin S. Braun |Shai Shimony |Richard Stone |Daniel DeAngelo |Jacqueline Garcia | +1 more

AbstractMutations in the cohesin complex components (STAG2, RAD21, SMC1A, SMC3, and PDS5B) are recurrent genetic drivers in myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML). Whether the different cohesin subunit mutations share clinical characteristics and prognostic significance is not known.

May 16, 2024 | onlinelibrary.wiley.com | Rebecca Bystrom |Jan Philipp Bewersdorf |Shai Shimony |Rory M. Shallis |Yiwen Liu |guillaume BERTON | +9 more

To the Editor: Intensive induction chemotherapy followed by consolidation therapy with additional chemotherapy and/or an allogeneic hematopoietic stem cell transplant (allo-SCT) is the standard of care for younger and fit patients with acute myeloid leukemia (AML).1 For older AML patients or those deemed unfit for intensive chemotherapy, the addition of the BCL2 inhibitor venetoclax to hypomethylating agents (HMA + VEN) has been shown to improve overall survival (OS) compared with HMA...

May 8, 2024 | nature.com | Qingyu Luo |Miguel Prado |Xiaowei Wu |Ran Xu |Peter van Galen |John G. Doench | +4 more

AbstractPhosphoinositide-3-kinase-γ (PI3Kγ) is implicated as a target to repolarize tumour-associated macrophages and promote antitumour immune responses in solid cancers1,2,3,4. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening with functional analyses across acute leukaemias, we define a selective dependency on the PI3Kγ complex in a high-risk subset that includes myeloid, lymphoid and dendritic lineages.