Bernard Henrissat

Oct 22, 2024 | nature.com | Darryl A Wesener |Megan Hill |Nicolas Terrapon |Bernard Henrissat |Dmitry A. Rodionov |Semen A Leyn | +1 more

AbstractSynthetic glycans (SGs) containing glycosidic linkages and structures not identified in nature offer a means for deliberately altering microbial community properties. Here pools of SG oligosaccharides were generated via polymerization of monosaccharides and screened for their ability to increase saccharolytic Bacteroides in ex vivo cultures of human fecal samples.

Mar 18, 2024 | nature.com | Hao-Wei Chang |Cyrus Zhou |Kali M. Pruss |Clara Kao |Matthew C. Hibberd |Hannah Lynn | +12 more

AbstractMicrobiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dense standard nutritional intervention.

Feb 22, 2024 | nature.com | Yoshiki Narimatsu |Christian Büll |Qinghua Liao |Francisco Corzana |Carme Rovira |Bernard Henrissat | +3 more

AbstractMicrobes utilize polysaccharides to protect their surfaces and build biofilms, whereas metazoans employ large mucins densely decorated with O-glycans to protect surfaces and keep microbes at a distance. However, gut microbes in mucus also feed on host mucins, thus imposing a need for continuous renewal to maintain protection, clearance and mucus homeostasis. Glycopeptidases that can cleave mucins are known, but mucinases that specifically cleave mucins are not.

Dec 13, 2023 | nature.com | Matthew C. Hibberd |Daniel Webber |Cyrus Zhou |Hannah Lynn |Hao-Wei Chang |Aleksandr A. Arzamasov | +6 more

AbstractEvidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition1,2,3,4. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain compared with a calorically more dense conventional ready-to-use supplementary food in 12–18-month-old Bangladeshi children with moderate acute malnutrition4.

Sep 11, 2023 | pubs.acs.org | Yu Wang |Birte Svensson |Bernard Henrissat |Marie Sofie Møller

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2023, XXXX, XXXRETURN TO ARTICLES ASAPBiotechnology and Bi...Biotechnology and Biological TransformationsNEXTYu WangEnzyme and Protein Chemistry, Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark, Birte SvenssonEnzyme and Protein Chemistry, Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs.