Bernhard Dumoulin

Sep 17, 2024 | jci.org | Bernhard Dumoulin |Katalin Susztak |Konrad Hoeft |Sikander Hayat

AbstractFibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation.