Bertram Klinger

Oct 1, 2024 | journals.plos.org | Bertram Klinger |Charité-Universitätsmedizin Berlin |Humboldt-Universität zu Berlin |Isabel Rausch

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Klinger B, Rausch I, Sieber A, Kutz H, Kruse V, Kirchner M, et al. (2024) Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network. PLoS Comput Biol 20(10): e1012488. https://doi.org/10.1371/journal.pcbi.1012488Editor: Marc R.

Jun 6, 2024 | biorxiv.org | Patrick Metzger |Heiner Koch |Bertram Klinger |Katharina Kasack

AbstractThe expression of mutated RAS genes drives extensive transcriptome alterations. Perturbation experiments have shown that the transcriptional responses to downstream effector pathways are partially unique and non-overlapping, suggesting a modular organization of the RAS-driven expression program. However, the relationship between individual deregulated transcription factors and the entire cancer cell-specific genetic program is poorly understood.