Katharina Kasack

Jun 6, 2024 | biorxiv.org | Patrick Metzger |Heiner Koch |Bertram Klinger |Katharina Kasack

AbstractThe expression of mutated RAS genes drives extensive transcriptome alterations. Perturbation experiments have shown that the transcriptional responses to downstream effector pathways are partially unique and non-overlapping, suggesting a modular organization of the RAS-driven expression program. However, the relationship between individual deregulated transcription factors and the entire cancer cell-specific genetic program is poorly understood.