Bingcong Xiong

Aug 21, 2024 | nature.com | Mingkai Zhang |Matthew Chapman |Bhagyesh R. Sarode |James Chen |Eranthie Weerapana |Bingcong Xiong

AbstractAlthough aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug1. Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs2.