Matthew Chapman

Aug 21, 2024 | nature.com | Mingkai Zhang |Matthew Chapman |Bhagyesh R. Sarode |James Chen |Eranthie Weerapana |Bingcong Xiong

AbstractAlthough aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug1. Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs2.

Sep 25, 2023 | msn.com | Matthew Chapman

A record-setting findArchaeologists have discovered what is thought to be the world's oldest known wooden structure – and it dates back even further than experts thought possible. The new research, undertaken by a team from the University of Liverpool and the University of Aberystwyth, reports on a newly-excavated arrangement of logs at the archaeological site of Kalambo Falls in Zambia, which, at at least 476,000 years old, predates even the evolution of our own species, Homo sapiens.