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Jan 24, 2025 | 
science.org | Zhiwen Jiang |Patrick Sullivan |Tengfei Li |Bingxin Zhao |Xifeng Wang |Tianyou Luo | +9 more
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Nov 27, 2024 | 
medrxiv.org | Yue Stella Yu |Andrew Lakkis |Bingxin Zhao |Jin Jin
The authors have declared no competing interest. the National Institutes of Health (NIH) grant R00 HG012223. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Aug 5, 2024 | 
medrxiv.org | Tengfei Li |Jie Chen |Bingxin Zhao |Hui Chen
The authors have declared no competing interest. This study was supported in part by the U.S. National Institute On Aging (NIA) of the National Institutes of Health (NIH) grant (RF1AG082938, U01AG079847) and NIH grants (NS110791, MH116527, AR082684). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Jul 17, 2024 | 
nature.com | Bingxin Zhao |Bingxuan Li |Yue Yang |Yun Li |Jason Stein |Tengfei Li | +1 more
AbstractThe retina, an anatomical extension of the brain, forms physiological connections with the visual cortex of the brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship to brain structure and function is not well understood. In this study, we conducted a systematic cross-organ genetic architecture analysis of eye-brain connections using retinal and brain imaging endophenotypes.
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Mar 22, 2024 | 
nature.com | Junhao Wen |Bingxin Zhao |Guray Erus |Elizabeth Mamourian |Gyujoon Hwang |Jingxuan Bao | +5 more
AbstractThe complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10−8).
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Dec 12, 2023 | 
genome.cshlp.org | Shiying Wang |Ting Li |Bingxin Zhao |Wei Dai
1 1Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06510, USA; 2Department of Applied Mathematics, The Hong Kong Polytechnic University, Hong Kong, China; 3Department of Statistics and Data Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104-1686, USA; 4Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA; 5Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North...
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Sep 30, 2023 | 
biorxiv.org | Junhao Wen |Bingxin Zhao |Zhijian Yang |Guray Erus
AbstractThe complex biological mechanisms underlying human brain aging remain incompletely understood, involving multiple body organs and chronic diseases. In this study, we used multimodal magnetic resonance imaging and artificial intelligence to examine the genetic architecture of the brain age gap (BAG) derived from gray matter volume (GM-BAG, N=31,557 European ancestry), white matter microstructure (WM-BAG, N=31,674), and functional connectivity (FC-BAG, N=32,017).
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Jun 27, 2023 | 
arxiv.org | Bingxin Zhao
arXiv:2306.15779 (stat) Download a PDF of the paper titled High-dimensional statistical inference for linkage disequilibrium score regression and its cross-ancestry extensions, by Fei Xue and Bingxin Zhao Download PDF Submission history From: Fei Xue [ view email] [v1] Tue, 27 Jun 2023 20:00:01 UTC (8,413 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?)...
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Apr 15, 2023 | 
biorxiv.org | Junhao Wen |Bingxin Zhao |Zhijian Yang |Guray Erus
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