Bodie Curren

Nov 25, 2024 | nature.com | Bodie Curren

AbstractProstaglandin D2 (PGD2) signals via the DP1 and DP2 receptors. In Phase II trials, DP2 antagonism decreased airway inflammation and airway smooth muscle (ASM) area in moderate-to-severe asthma patients. However, in Phase III, DP2 antagonism failed to lower the rate of exacerbations, and DP2 as a target was shelved.

Jul 3, 2023 | nature.com | Stephan Brouwer |Bodie Curren |Nichaela Harbison-Price |Mark Davies

Correction to: Nature Reviews Microbiology https://doi.org/10.1038/s41579-023-00865-7. Published online 9 March 2023. In the version of this article initially published, the number of estimated deaths per year from rheumatic heart disease listed in Table 1 was written incorrectly as “>300” rather than “>300,000”. The error has been corrected in the HTML and PDF versions of the article.

Mar 9, 2023 | nature.com | Stephan Brouwer |Bodie Curren |Nichaela Harbison-Price |Mark Davies

AbstractStreptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or invasive diseases, with potential for triggering post-infection immune sequelae. GAS deploys a range of virulence determinants to allow colonization, dissemination within the host and transmission, disrupting both innate and adaptive immune responses to infection.

Feb 24, 2023 | nature.com | Mark Davies |Stephan Brouwer |Magnus G. Jespersen |Amanda J. Cork |Andrew Hayes |Miranda Pitt | +7 more

AbstractA new variant of Streptococcus pyogenes serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1global’ and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown.