Bratislav Misic

Dec 16, 2024 | journals.plos.org | Bratislav Misic

The brain is extraordinarily complex, encompassing billions of neurons. Connections among neurons promote the propagation of electrical signals, generating highly organized activity that encodes perception, cognition, and action. Propelled by exciting technological advances over the past 100 years, from the first electroencephalogram to modern high-field magnetic resonance imaging (MRI), neuroscientists have traditionally sought to record neural activity with ever-increasing detail [1].

Sep 11, 2024 | nature.com | Jakob Seidlitz |Golia Shafiei |Kate Merritt |Anthony David |Sarah Morgan |Rosa Ayesa-Arriola | +6 more

AbstractThe psychosis spectrum encompasses a heterogeneous range of clinical conditions associated with abnormal brain development. Detecting patterns of atypical neuroanatomical maturation across psychiatric disorders requires an interpretable metric standardized by age-, sex- and site-effect. The molecular and micro-architectural attributes that account for these deviations in brain structure from typical neurodevelopment are still unknown.

Oct 17, 2023 | nature.com | Justine Y. Hansen |Bratislav Misic

AbstractThe brain is a network of interleaved neural circuits. In modern connectomics, brain connectivity is typically encoded as a network of nodes and edges, abstracting away the rich biological detail of local neuronal populations. Yet biological annotations for network nodes — such as gene expression, cytoarchitecture, neurotransmitter receptors or intrinsic dynamics — can be readily measured and overlaid on network models.