Jakob Seidlitz

Sep 11, 2024 | nature.com | Jakob Seidlitz |Golia Shafiei |Kate Merritt |Anthony David |Sarah Morgan |Rosa Ayesa-Arriola | +6 more

AbstractThe psychosis spectrum encompasses a heterogeneous range of clinical conditions associated with abnormal brain development. Detecting patterns of atypical neuroanatomical maturation across psychiatric disorders requires an interpretable metric standardized by age-, sex- and site-effect. The molecular and micro-architectural attributes that account for these deviations in brain structure from typical neurodevelopment are still unknown.

Jul 8, 2024 | nature.com | Camille Williams |Jakob Seidlitz |Travis T. Mallard

Correction to: Nature Mental Health https://doi.org/10.1038/s44220-024-00272-8, published online 4 July 2024. In the version of the article initially published, in Fig. 1e, arrows were missing between the “p” and “INT” circles, and between the “TD” circle and “BIP” square. The figure has now been corrected in the HTML and PDF versions of the article. About this articleWilliams, C.M., Peyre, H., Wolfram, T. et al.

Jul 3, 2024 | nature.com | Camille Williams |Jakob Seidlitz |Travis T. Mallard

AbstractMental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity observed in psychopathology. However, the phenotypic and genetic structures of various psychopathology diagnoses may differ, raising questions about the validity and utility of these factors. Here we study the phenotypic and genetic factor structures of ten psychiatric conditions using UK Biobank and public genomic data.

Mar 27, 2023 | nature.com | Jakob Seidlitz |Aaron F. Alexander-Bloch |Dani S. Bassett |Maxwell Bertolero |Matthew Cieslak |Yong Fan | +2 more

Authors and AffiliationsPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USAValerie J. Sydnor, Bart Larsen, Azeez Adebimpe, Maxwell A. Bertolero, Matthew Cieslak, Sydney Covitz & Theodore D. SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USAValerie J. Sydnor, Bart Larsen, Jakob Seidlitz, Azeez Adebimpe, Aaron F. Alexander-Bloch, Dani S.

Feb 20, 2023 | nature.com | Andrew Grotzinger |Travis T. Mallard |Jakob Seidlitz

Quality control proceduresQuality control filters for estimating the genetic covariance and sampling covariance matrices followed the defaults in the Genomic SEM10 implementation of LDSC43.