Brent Doiron

Jan 13, 2025 | biorxiv.org | Michael Leone |Chengcheng Huang |Brent Doiron |Carnegie Mellon

AbstractSynaptic physiology is highly stochastic in the neocortex: immediately following an action potential, individual synapses release neurotransmitter unreliably, sometimes even failing to release any vesicles. However, theoretical models of neuronal networks typically neglect this well-established feature of biology, especially recurrent networks.

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Brent Doiron

AbstractA core problem in systems and circuits neuroscience is deciphering the origin of shared dynamics in neuronal activity: Do they emerge through local network interactions, or are they inherited from external sources? We explore this question with large-scale networks of spatially ordered spiking neuron models where a downstream network receives input from an upstream sender network.

Jan 3, 2024 | nature.com | Ian Antón Oldenburg |William D. Hendricks |Gregory Handy |Kiarash Shamardani |Brent Doiron

AbstractRecurrent cortical activity sculpts visual perception by refining, amplifying or suppressing visual input. However, the rules that govern the influence of recurrent activity remain enigmatic. We used ensemble-specific two-photon optogenetics in the mouse visual cortex to isolate the impact of recurrent activity from external visual input.