Brett M. Frye

Oct 6, 2023 | frontiersin.org | Kristy A Nielson |Aimee Axelrod Parker |Brett M. Frye

1. IntroductionAlzheimer’s disease (AD) is the most common form of dementia, leading to a globally heavy healthcare and economic burden (Jia et al., 2018, 2020). According to the National Institute on Aging and Alzheimer’s Association (NIA-AA) research framework, AD-related biomarkers are mainly classified into three existing groups, including amyloid-β (Aβ) deposition, pathologic tau aggregation, and neurodegeneration [AT(N)] (Jack et al., 2018; Scheltens et al., 2021).