Brian J Mickey

Oct 23, 2024 | jmedicalcasereports.biomedcentral.com | Marcela Smid |Adam Gordon |Kathleen Shangraw |Brian J Mickey |Rana Jawish

Depression is one of the most common and serious medical conditions affecting pregnant and postpartum people, impacting more than 1 in 10 individuals in this population [1]. Pregnancy causes changes in the hypothalamic–pituitary–adrenal axis that can worsen depression. Some individuals are more sensitive to changes in reproductive hormone levels during pregnancy and after delivery, which may increase their risk of developing perinatal depression (PND) [1].

Oct 14, 2024 | nature.com | Todd Lencz |Brian J Mickey |James W Murrough |Sean M. Nestor |Thomas Nickl-Jockschat |Sina Nikayin | +6 more

AbstractGenome-wide association studies (GWASs) of major depressive disorder (MDD) have recently achieved extremely large sample sizes and yielded substantial numbers of genome-wide significant loci. Because of the approach to ascertainment and assessment in many of these studies, some of these loci appear to be associated with dysphoria rather than with MDD, potentially decreasing the clinical relevance of the findings.

Oct 11, 2024 | biologicalpsychiatryjournal.com | Thomas Riis |Brian J Mickey

Keywordsultrasounddeep brain stimulationneuromodulationsubgenual cingulatesubcallosal cingulatedepressionGet full text accessLog in, subscribe or purchase for full access. References1. Hamani, C. ∙ Mayberg, H. ∙ Stone, S. ... The subcallosal cingulate gyrus in the context of major depressionBiological psychiatry. 2011; 69:301-3082. Seminowicz, D.A. ∙ Mayberg, H.S. ∙ McIntosh, A.R. ... Limbic-frontal circuitry in major depression: A path modeling metanalysisNeuroImage. 2004; 22:409-4183.

Feb 19, 2024 | biologicalpsychiatryjournal.com | Brian J Mickey |Thomas Riis |Daniel Feldman |Sarah Kwon

Excessive activity of the subcallosal cingulate (SCC) has been linked to depression. Direct and selective engagement of deep brain regions like the SCC is currently only possible with invasive surgical approaches.

Jan 11, 2024 | nature.com | Thomas Riis |Daniel Feldman |Brian J Mickey

AbstractTranscranial focused ultrasound provides noninvasive and reversible approaches for precise and personalized manipulations of brain circuits, with the potential to transform our understanding of brain function and treatments of brain dysfunction. However, effective applications in humans have been limited by the human head, which attenuates and distorts ultrasound severely and unpredictably. This has led to uncertain ultrasound intensities delivered into the brain.