James W Murrough

Oct 14, 2024 | nature.com | Todd Lencz |Brian J Mickey |James W Murrough |Sean M. Nestor |Thomas Nickl-Jockschat |Sina Nikayin | +6 more

AbstractGenome-wide association studies (GWASs) of major depressive disorder (MDD) have recently achieved extremely large sample sizes and yielded substantial numbers of genome-wide significant loci. Because of the approach to ascertainment and assessment in many of these studies, some of these loci appear to be associated with dysphoria rather than with MDD, potentially decreasing the clinical relevance of the findings.

Feb 7, 2024 | nature.com | Flurin Cathomas |Kenny Chan |Long Li |Lyonna F. Parise |Romain Durand-de Cuttoli |Eric M. Parise | +8 more

AbstractPsychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood.