Thomas Nickl-Jockschat

Dec 4, 2024 | nature.com | Thomas Nickl-Jockschat

AbstractDysfunctional glial cells play a pre-eminent role in schizophrenia pathophysiology. Post-mortem studies have provided evidence for significantly decreased glial cell numbers in different brain regions of individuals with schizophrenia. Reduced glial cell numbers are most pronounced in oligodendroglia, but reduced astrocyte cell densities have also been reported.

Oct 14, 2024 | nature.com | Todd Lencz |Brian J Mickey |James W Murrough |Sean M. Nestor |Thomas Nickl-Jockschat |Sina Nikayin | +6 more

AbstractGenome-wide association studies (GWASs) of major depressive disorder (MDD) have recently achieved extremely large sample sizes and yielded substantial numbers of genome-wide significant loci. Because of the approach to ascertainment and assessment in many of these studies, some of these loci appear to be associated with dysphoria rather than with MDD, potentially decreasing the clinical relevance of the findings.

Nov 4, 2023 | nature.com | Yann Vanrobaeys |Zeru Peterson |Snehajyoti Chatterjee |Li-Chun Lin |Thomas Nickl-Jockschat |Ted Abel | +2 more

Sleep deprivation has far-reaching consequences on the brain and behavior, impacting memory, attention, and metabolism. Previous research has focused on gene expression changes in individual brain regions, such as the hippocampus or cortex. Therefore, it is unclear how uniformly or heterogeneously sleep loss affects the brain. Here, we use spatial transcriptomics to define the impact of a brief period of sleep deprivation across the brain in male mice. We find that sleep deprivation induced pronounced differences in gene expression across the brain, with the greatest changes in the hippocampus, neocortex, hypothalamus, and thalamus. Both the differentially expressed genes and the direction of regulation differed markedly across regions. Importantly, we developed bioinformatic tools to register tissue sections and gene expression data into a common anatomical space, allowing a brain-wide comparison of gene expression patterns between samples. Our results suggest that distinct molecular mechanisms acting in discrete brain regions underlie the biological effects of sleep deprivation. Sleep deprivation impacts molecular changes across brain regions. Here, the authors utilize a spatial. transcriptomics approach to elucidate acute sleep deprivation-induced gene expression signature. across regions and subregions of the brain.

Sep 1, 2023 | biologicalpsychiatryjournal.com | Michael J. Hawrylycz |Thomas Nickl-Jockschat

1 Ruzzo E.K. Pérez-Cano L. Jung J.Y. Wang L.K. Kashef-Haghighi D. Hartl C. et al. Inherited and de novo genetic risk for autism impacts shared networks. Cell. 178: 850-866.e26 , 2 Amaral D. Geschwind D. Dawson G. Autism Spectrum Disorders. Oxford University Press, New York ), neuroimaging [reviewed in ( 3 Moreau C.A. Raznahan A. Bellec P. Chakravarty M. Thompson P.M. Jacquemont S. Dissecting autism and schizophrenia through neuroimaging genomics. Brain.

Aug 28, 2023 | biologicalpsychiatryjournal.com | Maya Evans |Ted Abel |Thomas Nickl-Jockschat

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