Brian K. Kobilka

Jul 3, 2024 | nature.com | Brian K. Kobilka

Apr 10, 2024 | nature.com | Jiawei Zhao |Matthias Elgeti |Tao Che |Brian K. Kobilka

AbstractThe µ-opioid receptor (µOR) is an important target for pain management1 and molecular understanding of drug action on µOR will facilitate the development of better therapeutics. Here we show, using double electron–electron resonance and single-molecule fluorescence resonance energy transfer, how ligand-specific conformational changes of µOR translate into a broad range of intrinsic efficacies at the transducer level.