Tao Che

Oct 9, 2024 | onlinelibrary.wiley.com | Cong Xu |Gaofeng Zhu |Yang Zhang |Tao Che

Supporting Information Filename Description hyp15295-sup-0001-Supinfo.docxWord 2007 document , 2.5 MB Data S1. References , and . 2016. “Biophysical Climate Impacts of Recent Changes in Global Forest Cover.” Science 351, no. 6273: 600–604. https://doi.org/10.1126/science.aac8083. 1988. “An Analysis of Stomatal Conductance.” PhD diss., Stanford University, Stanford, CA. , , and . 2022.

Apr 10, 2024 | nature.com | Jiawei Zhao |Matthias Elgeti |Tao Che |Brian K. Kobilka

AbstractThe µ-opioid receptor (µOR) is an important target for pain management1 and molecular understanding of drug action on µOR will facilitate the development of better therapeutics. Here we show, using double electron–electron resonance and single-molecule fluorescence resonance energy transfer, how ligand-specific conformational changes of µOR translate into a broad range of intrinsic efficacies at the transducer level.

Dec 6, 2023 | nature.com | Stefan Gahbauer |Joao M. Braz |Hye Jin Kang |Christian B. Billesbølle |Yongfeng Liu |Tao Che | +7 more

AbstractThe lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostaglandin synthesis, however, the disruption of upstream prostanoid biosynthesis can lead to pleiotropic effects including gastrointestinal bleeding and cardiac complications.

Aug 14, 2023 | nature.com | Tao Che

A universally effective method has been developed to enable cryo-electron microscopy structural determination of G protein–coupled receptors in various states. This method will accelerate structure-based drug discovery and enhance understanding of the activation mechanism for these receptors. Some progress has been made through the use of different methodological approaches to determine inactive-state GPCRs structures by cryo-EM (Fig. 1a–c).