-
Dec 3, 2024 | 
bmcpublichealth.biomedcentral.com | Byrne CD
The burden associated with NAFLD is becoming a major concern for global health systems [4], and due to a lack of targeted drug treatments, optimizing lifestyle through reasonable intervention has become the fundamental and crucial part of NAFLD treatment [32]. However, participation in structured lifestyle improvement programs may be affected by work and time constraints, making it difficult for patients to benefit [33, 34].
-
Sep 17, 2024 | 
bmcpublichealth.biomedcentral.com | Byrne CD |Sun Yat-sen
The data employed in this study originated from the China Xinjiang National Health Examination Program, carried out in the year 2021. To acquire a thorough grasp of the research framework and the criteria for participant selection adopted within this initiative, we direct interested readers to our preceding study [19]. This investigation collated health examination data from a substantial cohort, comprising a total of 9,382,225 individuals.
-
Sep 6, 2024 | 
gut.bmj.com | Christopher Byrne |Corey KE |Byrne CD |Sungho Bea
MethodsThis population-based cohort study used nationwide health administrative claims data (1 September 2014 to 31 December 2022) obtained from the National Health Insurance Service (NHIS) of Korea.
-
Aug 21, 2024 | 
cardiab.biomedcentral.com | Byrne CD |Universidad de Navarra
A total of 181 patients from 547 patients fulfilled criteria to be included in the analysis. Figure 1 summarizes exclusion criteria. Mean age was 55.9 ± 8.5 years and 76.8% were men. One hundred sixteen (64%) patients had SLD, of which 87 (75%) had a BAAT Score ≥ 2. A hundred and four (57%) patients had abnormal EATi. Table 1 displays the main demographic, clinical and laboratory characteristics of all the patients included. Mean duration of diabetes was 8 ± 7,8 years.
-
Aug 5, 2024 | 
link.springer.com | Byrne CD
AbstractType 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) are prevalent metabolic disorders with overlapping pathophysiological mechanisms. A comprehensive understanding of the shared molecular pathways involved in these conditions can advance the development of effective therapeutic interventions. We used two datasets sourced from the Gene Expression Omnibus (GEO) database to identify common differentially expressed genes (DEGs) between T2D and NAFLD.
-
Jul 11, 2024 | 
link.springer.com | Byrne CD
AbstractAlthough the inherited risk factors associated with fatty liver disease are well understood, little is known about the genetic background of metabolic dysfunction-associated steatotic liver disease (MASLD) and its related health impacts. Compared to non-alcoholic fatty liver disease (NAFLD), MASLD presents significantly distinct diagnostic criteria, and epidemiological and clinical features, but the related genetic variants are yet to be investigated.
-
Jun 14, 2024 | 
onlinelibrary.wiley.com | Byrne CD |Alessandro Mantovani |Giovanni Targher |Kalantar-Zadeh K
Several studies have reported a significant association between the PNPLA3 rs738409 G allele and chronic kidney disease. Epidemiological evidence about a direct effect of the PNPLA3 rs738409 G allele on the risk of developing kidney dysfunction is limited. PNPLA3 is expressed in renal podocytes, pericytes, and proximal tubule cells, suggesting that the mutant PNPLA3 protein is involved in developing renal steatosis and fibrosis.
-
May 19, 2024 | 
bmcpublichealth.biomedcentral.com | Byrne CD
Table 1 displays the baseline characteristics of individuals in the present study (N = 23,129). A total of 1,123 (4.9%) individuals were identified as having severe NAFLD over a median follow-up period of 13.6 years. Overall, participants had a mean (SD) age of 60 (6.9) years and were predominantly male (62.2%).
-
Apr 13, 2024 | 
link.springer.com | Byrne CD
AbstractThe diagnosis and comprehension of nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) are gaining a better understanding. In this study, we examined the association between visceral fat area and skeletal muscle mass ratio (VSR) and the prevalence of MASLD in a Chinese population.
-
Mar 13, 2024 | 
bmcpublichealth.biomedcentral.com | Byrne CD
All procedures, including sampling and examination, were conducted in accordance with the principles outlined in the Declaration of Helsinki and its subsequent revisions. A total of 53 participants from Fuyang peoples’ hospital were analyzed. All participants’ FF values were recorded by MRI fat quantitative examination (FF < 5% represented the normal group, 5 ≤ FF ≤ 14% represented mild fatty liver, and FF ≥ 14% represented moderate and severe fatty liver) [42].
