Giovanni Targher

2 months ago | nature.com | Giovanni Targher |Christopher Byrne |Kaijun Niu

AbstractA skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines with chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is uncertain. This study examined the associations between SMS and the risk of CKD in MASLD population.

Mar 11, 2025 | digitalcommons.library.tmc.edu | Christopher Byrne |Dan-Qin Sun |Giovanni Targher |David Wheeler

BACKGROUND: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the term non-alcoholic fatty liver disease (NAFLD).

Feb 13, 2025 | gut.bmj.com | Christopher Byrne |Giovanni Targher |Alessandro Mantovani |Herbert Tilg

FootnotesContributors GT, AM, CDB and HT contributed equally to the manuscript. GT is the guarantor for the overall content of the manuscript. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. Competing interests HT is an associate editor of the journal, and GT is an editorial board member of the journal. The authors do not have other potential conflicts of interest to disclose.

Jul 11, 2024 | gut.bmj.com | Alessandro Mantovani |Herbert Tilg |Giovanni Targher |Medizinische Universität Innsbruck

FGF-21 analogues for treatment of non-alcoholic steatohepatitis and fibrosis: a meta-analysis with fragility index of phase 2 randomised placebo-controlled trials Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Jun 14, 2024 | onlinelibrary.wiley.com | Byrne CD |Alessandro Mantovani |Giovanni Targher |Kalantar-Zadeh K

Several studies have reported a significant association between the PNPLA3 rs738409 G allele and chronic kidney disease. Epidemiological evidence about a direct effect of the PNPLA3 rs738409 G allele on the risk of developing kidney dysfunction is limited. PNPLA3 is expressed in renal podocytes, pericytes, and proximal tubule cells, suggesting that the mutant PNPLA3 protein is involved in developing renal steatosis and fibrosis.