Byron Creese

1 month ago | themirror.com | Brigid Brown |Byron Creese

Dementia is characterized by a range of symptoms associated with the ongoing decline of brain function. Over time, the decline leads to problems with memory, behavior, and even movement. While many are familiar with common dementia symptoms such as memory loss, slower thinking speed, and difficulty carrying out daily tasks, there are lesser-known signs that could indicate the early stages of the disease.

Jan 14, 2025 | nature.com | Lachlan Gilchrist |Thomas P. Spargo |Rebecca Green |David Howard |Jackson G. Thorp |Brett N. Adey | +25 more

AbstractDepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship.

Sep 4, 2024 | jnnp.bmj.com | Byron Creese |Matthew Lennon |Grant Rigney |Dag Aarsland

The Brain Injury Screening Questionnaire (BISQ)12 was used to collect data on previous concussions/TBIs. It was an optional, self-administered battery within the PROTECT study, and of eligible participants with sufficient data in the PROTECT study, 4379 individuals did not complete the BISQ and 15 764 did. The baseline characteristics of responders and non-responders are compared in online supplemental table S2 to assess for self-selection bias.

Dec 12, 2023 | alzres.biomedcentral.com | Byron Creese |Biomedical Science |Brunel London

ReferencesLambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet. 2013;45:1452–8. Article  PubMed  PubMed Central  Google Scholar  de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, et al. Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nat Commun. 2021;12:3417.

Nov 20, 2023 | jneuroinflammation.biomedcentral.com | Byron Creese |Brunel London

Participants were recruited from existing research cohorts established at King’s College London, including the Alzheimer’s disease research cohorts AddNeuroMed and KHP-DCR (King’s Health Partners—Dementia Case Register) [32], and PROTECT (Platform for Research Online to investigate Genetics and Cognition in Aging—REC reference 13/LO/1578), a cohort of healthy older adults. All studies had consent for re-contact for future research studies [33].