Biomedical Science

Jan 6, 2025 | journals.plos.org | Zeynep Yerlikaya |Biomedical Science |College Dublin |Yuting Yin

Loading metrics Open Access Peer-reviewedResearch Article Citation: Yerlikaya Z, Miranda-CasoLuengo R, Yin Y, Cheng C, Meijer WG (2025) Clade-1 Vap virulence proteins of Rhodococcus equi are associated with the cell surface and support intracellular growth in macrophages. PLoS ONE 20(1): e0316541.

Nov 29, 2024 | jneuroinflammation.biomedcentral.com | Biomedical Science |Queen’s College Belfast

Heterozygous Trpv2+/– and wildtype Trpv2+/+ rats (Sprague Dawley background) were bred and maintained until 3 months of age for the study. Original breeders were generated from SAGE labs, as previously described [19], and both groups were obtained from heterozygous breeders as homozygous Trpv2−/− animals are not viable. Rats were housed in the Biological Services Unit (BSU) at Queen’s University Belfast under SPF and normal lighting conditions (12-hour light/dark cycle).

Oct 18, 2024 | jmedicalcasereports.biomedcentral.com | Jean Claude |Biomedical Science

A 20-year-old female Black African young adult presented at the out-patient department for routine consultation and follow-up. She was previously diagnosed with type 1 diabetes at the age of 14 years following presenting with an abrupt onset of osmotic symptoms (thirst, polyuria, and unexplained weight loss), random plasma glucose at 471 mg/dL (25.9 mmol/L), and ketonuria at 8.0 mmol/L. Her weight at the time of diabetes diagnosis was 50 kg, and HbA1c was at 10.9%.

Sep 23, 2024 | cell.com | Biomedical Science

KeywordsATMataxia telangiectasiaClinGenACMGvariant interpretationbreast cancerrules specificationsVariant Curation Expert PanelclassificationIntroductionThe widespread adoption of low-cost, high-throughput, next-generation-sequencing (NGS)-based, multi-gene panel tests has led to a substantial increase in the detection of germline sequence variants.

Sep 13, 2024 | chemistry-europe.onlinelibrary.wiley.com | Tuhin Das |Eva F. Hayball |Alix C. Harlington |Biomedical Science

Introduction Cytochrome P450 enzymes (CYPs) are a group of heme-thiolate enzymes that catalyse the regio- and stereo-selective oxidation of carbon-hydrogen (C−H) bonds in organic compounds.1 The enzymes participate in a wide range of chemical reactions including; decarboxylation, epoxidation, desaturation, dealkylation, and sulfoxidation.2 They are therefore of significant interest as biocatalysts to simplify synthetic routes involving selective late-stage functionalisation of complex...